Is interleukin-17 implicated in early knee osteoarthritis pathogenesis as in rheumatoid arthritis?

Abstract Background Interleukin-17 (IL-17) is a cytokine that promotes activation of multiple catabolic pathways resulting in cartilage and tissue damage. It has features making it increasingly attractive as biological marker, especially rheumatoid arthritis (RA) osteoarthritis (OA). However, its expression heterogeneous; not all patients’ exhibit high IL-17 levels, level along the disease course still challenging to predict. Aim work The objectives this study were compare serum levels patients with early knee OA RA patients, determine correlation activity if correlated functional scores both OA. Subjects methods Twenty (32.7 ± 3.7) years included. Diagnosis was based on Luyten et al. 2012 classification (early 2012). This also included 25 aged 32.8 5.1 years, diagnosis according 2010 ACR-EULAR criteria for RA. current control group 20 healthy volunteers 31.9 3.2 years. assessed by using ELISA technique. Results Serum significantly (5.2 pg/ml) higher (5.9 compared (4.9 ( P < 0.001). Conclusions increased suggests pathogenic role disease. positive severity OA-related pain proposes may be potential marker target treatment pain.